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Computational Protein Engineer

Job Juncture

Location: Rockville, Maryland
Type: Non-Remote
Posted on: May 11, 2026
Jobs #43756
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Computational Protein Engineer
Salary: $125,000 - $155,000 per year
Location: Rockville, MD
Posted: May 11 2026
Minimum Degree:
Relocation Assistance: Available
Our client is a leading biotech firm advancing innovative antibody and protein engineering programs.
They seek a Senior Scientist, Protein Engineering to lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.
The ideal candidate will take on the following responsibilities:
• Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design
• Drive protein expression, purification, and characterization workflows across multiple formats
• Design and execute binding and functional assays to evaluate and iterate on engineered proteins
• Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
• Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies
• Manage CRO partnerships including experimental design, vendor communication, and internal reporting
The ideal candidate will possess the following qualifications:
• PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience
• Hands-on expertise in protein expression, purification, and characterization
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
• Peer-reviewed publications and/or patents in antibody or protein engineering
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
• Proven ability to lead technical teams and manage complex, multi-faceted projects
• Outstanding written and verbal communication skills
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