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Research Scientist I

H. Lee Moffitt Cancer Center

Location: 33612
Type: Full-Time, Non-Remote
Posted on: September 14, 2022
This job is no longer available from the source.
Research Scientist I Science & Research Hours: varies Day Shift - Full Time Paygrade/Wages/Salary Info: RCH ES1 - 32.4000 - 42.1300
The Oskarsson laboratory studies the molecular interactions between cancer cells and the microenvironment in metastasis and in response to therapeutic intervention. The molecular context generated by the metastatic microenvironment evolves with progression of the disease and is an important determinant of cancer cell fitness. Our objective is to dissect both cellular and extracellular matrix (ECM) components of the microenvironment in metastasis. The group has shown how stress signals induced by chemotherapy can promote the induction of specific ECM components resulting in generation of a metastatic niche that can limit therapeutic efficacy (Insua-Rodriguez et al EMBO Molecular Medicine 2018). The work of the group has also revealed novel pro-metastatic interactions of disseminated cancer cells with fibroblasts and with endothelial cells in the lungs (Pein et al Nature Communications 2020 and Hongu et al Nature Cancer 2022). Ongoing work involves the characterization of disseminated cancer cells that are dormant in different visceral organs but maintain growth potential. The successful candidate will employ multidisciplinary approaches using biochemistry, molecular and cell biology, transcriptomics, genomics, proteomics, computational biology and mouse models to answer basic and translational scientific questions. An important part of our research program is to validate and confirm our discoveries in the context of human cancer using a variety of methods in collaboration with clinicians and pathologists at the Moffitt Cancer Center. Our goal is to identify novel mechanisms of metastasis that can be exploited to improve diagnosis, treatment, and survival of cancer patients. Position Highlights: The Research Scientist is a non-tenure track researcher who assumes the direct responsibility of conducting and performing experiments or directly overseeing experimentation as part of a research team under the general guidance of an Investigator. The Research Scientist only activity is research and related support activities and the efforts of the Research Scientist are focused on goals of the laboratory they are part of.# # The Ideal Candidate: Highly motivated and driven with interest in research on cancer metastasis Substantial laboratory experience (molecular and cellular biology) and the ability to design and perform own experiments. Excellent communication skills (oral and written) # Self-motivated and has ability to work independently as well as in a collaborative environment. Experience in working with mouse models Bioinformatics skills are a plus (but not required) Responsibilities: Plans and performs experiments directed towards answering specific scientific questions with limited supervision under the general guidance of the Investigator. Interacts closely with Investigator and other researchers within the Investigator Laboratory and conducts relevant background research including literature searches and reviews. Assists in planning and developing research projects within the laboratory under the Investigator#s direction. May work individually or may have significant oversight over other lexperiencedence research personnel. Credentials and Qualifications: Minimum of an M.D. or Ph.D. in Biological Science or related field with three to five years of postdoctoral experience.