Research Scientist I– Clonal Evolution of Cancer Science & Research Hours: Mon-Fri Day Shift - Full Time Paygrade/Wages/Salary Info: RCH ES1 - 30.8600 - 40.1200
Research Scientist I# Clonal Evolution of Cancer A main problem in the treatment of advanced cancers is the incertitude at which we#predict how individual patients will respond to cytotoxic agents, especially in the#long run. Despite a wealth of genomic information, #more-is-better# and #one-size-fits-all##remain the principles according to which cytotoxic agents are administered. # We seek applications from individuals to test the potential of the very long-term legacy#that DNA-damage entails on a cell # genomic instability # as new biomarker of DNA damage response. # Position Highlights: This Postdoc will be part of a multi-disciplinary team in the Department of Integrated#Mathematical Oncology (IMO), where wet- and dry-lab#components of in-vitro and in-vivo experiments are seamlessly integrated to meet the#project#s central challenge: forecasting how phenotypes of coexisting tumor clones diverge when exposed to specific microenvironments. # The Ideal Candidate: Extensive experience working in both, in-vitro and in-vivo systems. Has#an interest in learning the basics of programming to trace long-term trends in the clonal evolution of cell populations. # Responsibilities: Communicate with computer scientists and mathematicians. Will expose cell lines to different environments (including nutrient limitations, cytotoxic agents) and quantify drug-induced changes in their clonal composition from different perspectives, including their transcriptome and morphology. # Credentials and Qualifications: MD or PhD in Cancer Biology, Genetics, Pharmacology or Molecular Biology or related field with three to five years of postdoctoral experience is required. This position brings a unique opportunity to be part of the forefront of this multidisciplinary field, in an environment where experimental and computational domains interact routinely and efficiently. It includes funded travel to attend research conferences. # Interested applicants should send a cover letter, current CV, contact information for three references, and a brief personal statement describing their perspective on the co-evolution of tumor cells and therapy to Dr. Andor at Noemi.Andor@Moffitt.org.